The Collegiate House was built between 1777 and 1780 on the north side of the Luisenplatz as seat of the ministeries. The plans were made by the chief planning officer of Hanau, Franz Ludwig von Cancrin.

The west wing was added in 1845, the east wing in 1889. Both connect the collegiate building with the new chancellor's building (Kanzleigebäude) on the Mathildenplatz, which was built in 1825 to plans from Georg Moller. Today the "Kollegiengebäude" is seat of the Darmstadt regional council.